Brain-stem relays mediating stimulation-produced antinociception from the lateral hypothalamus in the rat
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Brain-stem relays mediating stimulation-produced antinociception from the lateral hypothalamus in the rat.
Several lines of evidence have demonstrated a role for the lateral hypothalamus (LH) in an endogenous system of descending inhibition. The present study, in rats lightly anesthetized with pentobarbital, was undertaken to examine systematically the organization in the brain stem of pathways mediating descending inhibition of the nociceptive tail flick (TF) reflex produced by focal electrical sti...
متن کاملIntra-accumbal orexin-1 receptors are involved in antinociception induced by stimulation of the lateral hypothalamus in the formalin test as an animal model of persistent inflammatory pain
Orexin, mainly produced by orexin-expressing neurons in the lateral hypothalamus (LH), plays an important role in pain modulation. Moreover, it is shown that the nucleus accumbens (NAc) is one of the important areas involved in this modulation. Orexin-1 (OX1) and orexin-2 (OX2) receptors are densely distributed in the NAc. The study investigated the involvement of OX1 receptors in the NAc on an...
متن کاملIntra-accumbal orexin-1 receptors are involved in antinociception induced by stimulation of the lateral hypothalamus in the formalin test as an animal model of persistent inflammatory pain
Orexin, mainly produced by orexin-expressing neurons in the lateral hypothalamus (LH), plays an important role in pain modulation. Moreover, it is shown that the nucleus accumbens (NAc) is one of the important areas involved in this modulation. Orexin-1 (OX1) and orexin-2 (OX2) receptors are densely distributed in the NAc. The study investigated the involvement of OX1 receptors in the NAc on an...
متن کاملLateral hypothalamus chemical stimulation-induced antinociception was attenuated by injection of dopamine D1 and D2 receptor antagonists in the ventral tegmental area
Introduction: Stimulation or inactivation of the lateral hypothalamus (LH) produces antinociception. Studies showed a role for the ventral tegmental area (VTA) in the antinociception induced by LH chemical stimulation through the orexinergic receptors. In this study, we assessed the role of intra-VTA dopamine D1 and D2 receptors in antinociceptive effects of cholinergic agonist, carbachol, m...
متن کاملSpread of current from monopolar stimulation of the lateral hypothalamus.
the boundary of a system. The characteristics of the threshold bared of insulation. The effects of stimulation were tested gradients suggest that, with intensities on the order of 25 pa, the for 5 days with the electrode at each lateral hypothalamic effective spread of current from small monopolar electrodes may site; each week the electrodes were moved approximately be as little as l/8 mm. The...
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ژورنال
عنوان ژورنال: The Journal of Neuroscience
سال: 1988
ISSN: 0270-6474,1529-2401
DOI: 10.1523/jneurosci.08-07-02652.1988